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In patients with chronic respiratory issues, such as chronic obstructive pulmonary disease (COPD), the respiratory drive can be affected by long-term hypoxia and hypercapnia (elevated carbon dioxide levels). These patients often become accustomed to lower levels of oxygen in their blood, which might diminish the normal respiratory response to high oxygen concentrations.

When supplemental oxygen is administered, these patients may not exhibit an immediate improvement in their breathing for a few reasons. First, their respiratory centers may be less responsive to oxygen levels due to chronic adaptation, leading to little to no effect. Additionally, if the oxygen increases their arterial oxygen levels excessively, it can actually lead to decreased respiratory drive and retention of carbon dioxide.

Overall, administering oxygen to these patients must be done carefully, as they might not show the expected positive response that is often seen in patients with acute respiratory distress or those without chronic issues. Hence, the typical response can indeed be one of minimal to no change in breathing patterns.